Products
5-Fluorocytosine
Structural Formula
Zvenyama
Kuonekwa: White powder
Density: 1.3990 (kufungidzira)
Nzvimbo yekunyungudika: 298-300 °C (December) (lit.)
Boiling point.
Refractivity
Flash point.
Safety Data
Hazardous category.
Nhamba Yekutakura Zvinhu Nengozi.
Packing category.
Application
Flucytosine nemuromo inoshandiswa kurapa zvirwere zvakakomba zvinokonzerwa nemhando dzeCandida kana Cryptococcus neoformans.Inogonawo kushandiswa pakurapa chromomycosis (chromoblastomycosis), kana hutachiona hunokonzera hutachiona.Flucytosine haifanirwe kushandiswa sechinhu chega chega muzvirwere zvinotapukira zvefungal nekuda kwekushomeka kweantifungal mhedzisiro uye kukurumidza kukura kwekupokana, asi pamwe chete neamphotericin B uye/kana azole antifungals senge fluconazole kana itraconazole.Zvirwere zviduku zvakadai secandidal cystitis zvinogona kurapwa neflucytosine chete.Mune dzimwe nyika, kurapwa nekunonoka intravenous infusions kweasingapfuuri svondo inzira yekurapa, kunyanya kana chirwere ichi chiri munjodzi.
Zvirwere zvakakomba zvefungal zvinogona kuitika kune avo vasina immunocompromised.Vanhu ava vanobatsirwa nemishonga yemubatanidzwa inosanganisira flucytosine, asi chiitiko chemhedzisiro yemubatanidzwa therapy, kunyanya neamphotericin B, inogona kunge yakakwira.
5-Fluorocytosine inoshandiswa kurapa fungal zvirwere zvinokonzerwa neCryptococcus uye Candida, zvakadai sefungal sepsis, endocarditis, meningitis, uye antifungal agents kumapapu uye urinary tract infections.
Hunhu
Ichi chigadzirwa chine yakakwira antifungal chiitiko kurwisa Candida spp.uye Candida spp.uye zvakare ine antibacterial chiitiko kurwisa Bacillus spp.uye Mycobacterium spp.Chigadzirwa chacho chinorwisa mabhakitiriya pakudzika kwakadzika uye fungicidal pakakwirira.Iyo nzira yekuita ndeyekuvhara synthesis yefungal nucleic acid.Iyo fungus iri nyore kuburitsa kushorwa kune ichi chigadzirwa.
Zvekungwaririra
Yakasanganiswa neamphotericin B, ine synergistic effect, asi inogona kuderedza kubuda kwechigadzirwa ichi kubva muitsvo uye kuwedzera kuwanda kweropa, izvo zvinogona kukonzera huturu muitsvo neropa.Nokudaro, huwandu hwepamusoro hweropa hunofanira kuongororwa uye kuchengetedzwa pa 50-75μg / ml, isingapfuuri 100μg / ml;kushandiswa kwebhonzo inhibitors kunogona kuwedzera hematologic toxicity yechigadzirwa ichi.
Ichi chigadzirwa chinogona kukonzera ① kusvotwa, manyoka, mapundu, nezvimwe;② kukuvara kwechiropa, kunyanya kukwidziridzwa kwekushanda kwechiropa zviratidzo, asiwo hepatomegaly kana kunyange hepatic necrosis;③ myelosuppression leukocyte uye kuderedza platelet, dzimwe nguva kunogona kukonzera ropa rose cytopenia.Inouraya granulocytic leukocyte kushomeka uye kubvisa anemia zvakare zvakataurwa;④ kufungidzira, musoro uye vertigo zvakataurwa zvakare.Naizvozvo, shandisa nekuchenjerera kune varwere vane hepatic kana renal impairment, kusagadzikana kweropa, uye kudzvinyirira kwemwongo.Mufananidzo weropa weperipheral, chiropa uye itsvo kushanda uye kuita weti kunofanirwa kuongororwa nguva nenguva kana uchishandisa chigadzirwa ichi.Iyo ine teratogenic mhedzisiro mukuedzwa kwemhuka, uye inofanirwa kushandiswa nekuchenjerera muvakadzi vane nhumbu.
Maitiro asina kunaka anosanganisira yakakwira transaminases, alkaline phosphatase, gastrointestinal zviratidzo, leukopenia, anemia, thrombocytopenia, renal kukanganiswa, kutemwa nemusoro, kuderera kwekuona kwekuona, kufungidzira, kurasikirwa nekunzwa, dyskinesia, kuderera kweserum potassium, calcium uye phosphorus kukosha, uye allergic reactions (semuenzaniso .
