Bucladesine

Tsanangudzo Pfupi

Zita: Bucladesine
Zita remadunhurirwa: N-6,O-2′-Dibutyryl adenosine cyclic 3′:5′-monophosphate;N-(9-beta-D-Ribofuranosyl-9H-furin-6-yl)-butyramide cyclic 3′,5′-(hydrogen phosphate) 2′-butyrate
Nhamba yeCAS: 16980-89-5
Nhamba yekupinda yeEINECS: 241-059-4
Molecular formula: C18H23N5NaO8P
Masikuru uremu:491.37

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Product Detail

Product Tags

Structural Formula

Zvinhu Zvenyama
Chitarisiko: White solid solid crude product
Kuchengetedza mamiriro: -20°C
Solubility H2O: 50 mg/mL

Safety Data
Ndezvezvinhu zvakajairika

Application
Dibutyryl cyclic adenosine monophosphate sodium inotorwa kubva ku cyclic adenosine monophosphate, iyo inoshandiswa kurapa cardiogenic shock uye heart failure.Muna 1999, Dibutyryl cyclic adenosine monophosphate sodium mafuta yakagadziridzwa kurapa utachiona hweganda uye ronda reganda.

Kugadzirira kwe sodium dibutyryl cyclophosphate adenosine: Mu flask ine cyclophosphate adenosine zvishoma nezvishoma wedzera aqueous sodium hydroxide solution (3 mol / L) inodonha, iyo inodzorwa tembiricha, inodonha inopedza kudziya kusvika kukamuri tembiricha, gadzirisa pH kusvika 7 ~ 8 neHCl mhinduro. 20%), wedzera anhydrous ethanol kunaya kwewhite solid, filtration, kuomesa kuti uwane chena yakasimba sodium munyu;iyo sodium munyu uye n-butyl anhydride pasi pekuchengetedzwa kweN2 kudziya kusvika ku140 ℃ maitiro.TLC yekutarisa, kuita kwacho kunenge kwapera uye ndokudzikiswa kusvika mukamuri tembiricha, zvishoma nezvishoma wedzera methyl tert-butyl ether, maitiro ekukurudzira kwakasimba, Chemicalbook kuwana ingangoita chena yakasimba crude chigadzirwa.Musanganiswa wemethyl tert-butyl ether uye acetone yakamiswa zvakare kuti iwane chena hupfu hwakanangwa chigadzirwa.Biological activityDibutyryl-cAMP(Bucladesine,dbcAMP) is a cell-permeable PKA activator inoita nekutevedzera endogenous cAMP.Dibutyryl-cAMP(Bucladesine) is also phosphodiesterase(PDE) inhibitor.
In vitro zvidzidzo: Dibutyryl-cAMP inhibits neuronal glucose kutora kuburikidza nePKA activation.Muchikonzo hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase kutaura uye NF-kappaB inosunga basa.dibutyrChemicalbookyl-cAMP zvakare inhibits TNFalpha-induced rod cell apoptosis nekudzivisa FADD upregulation.
In vivo zvidzidzo: Mumuenzaniso wembeva, Bucladesine (600nM/mbeva, ip) yakadzoreredza zinc chloride uye lead acetate induced evasive memory kuchengetedza kukanganisa.

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