Products
Dexamethasone
Structural Formula
Zvenyama
Kuonekwa: chena poda
Density: 1.1283
Kunyungudika: 262-264°C
Kuvira kwenzvimbo: 568.2±50.0°C
Safety Data
Chikamu chenjodzi: General zvinhu
Application
Inonyanya kushandiswa kune anti-inflammatory uye anti allergic.Inokodzera rheumatoid arthritis nezvimwe zvirwere zve collagen.
Dexamethasone (DXMS) yakatanga kugadzirwa muna 1957 uye yakanyorwa muWHO Essential Medicines Standard List semumwe wemishonga yakakosha kumasystem ehutano hweveruzhinji.
Musi waChikumi 16, 2020, WHO yakati mhedzisiro yekuongororwa kwekiriniki kuUnited Kingdom yakaratidza kuti dexamethasone inogona kuponesa hupenyu muvarwere vane neocoronary pneumonia, kuderedza kufa nechikamu chimwe chete muzvitatu chevarwere vari pamhepo inofefetera uye nechikamu chimwe muzvishanu chevarwere vari kurapwa. oxygen chete.
Dexamethasone is a synthetic corticosteroid inogona kushandiswa kurapa zvakasiyana-siyana zvemamiriro ezvinhu, kusanganisira rheumatic zvirwere, mamwe mamiriro eganda, allergy yakaoma, asthma, chronic obstructive pulmonary disease, yakarurama laryngitis, cerebral edema, uye zvichida pamwe chete nemishonga inorwisa mabhakitiriya kune varwere vane chirwere. tibhii.Iine chiyero chepamuviri cheC muUnited States, chinoda kuongororwa kuti kushanda kwemushonga kunodarika mhedzisiro isati yaitwa, uye chiyero cheA muAustralia, chinoratidza kuti chinowanzoshandiswa kuvakadzi vane pamuviri. uye kuti hapana humbowo hwekukuvara kwe "fetus".
Pharmacological madhara
Dexamethasone, inozivikanwawo seflumethasone, fluprednisolone, uye dexamethasone, iglucocorticoid.Zvigadzirwa zvayo zvinosanganisira hydrocortisone, prednisone, nezvimwewo. Migumisiro yaro yemishonga inonyanya kupikisa, anti-toxic, anti-allergic uye anti-rheumatic, uye inoshandiswa zvakanyanya mumakiriniki maitiro.Yayo plasma T1/2 maminitsi 190 uye tishu T1/2 mazuva matatu.Nhamba yepamusoro yeropa ye dexamethasone sodium phosphate kana dexamethasone acetate inosvika paawa nemaawa masere zvichiteerana mushure mejekiseni remumuscular.Iyo plasma protein inosunga chiyero chechigadzirwa ichi yakaderera pane yeimwe corticosteroids.Basa rinopesana nekuputika kwe0.75 mg yakaenzana ne5 mg ye prednisolone.Adrenocorticosteroids, anti-inflammatory, anti-allergic uye anti-toxic migumisiro yakasimba kudarika prednisone, uye zvinokonzerwa nekuchengetedza sodium uye potassium excretion yakanyanya kujeka.
1. Anti-inflammatory effect: Inogona kuderedza uye kudzivirira mhinduro yetishu pakuputika, nokudaro kuderedza kuratidzwa kwekuputika.Mahomoni anodzivisa kuunganidzwa kwemasero ekuputika, kusanganisira macrophages uye leukocytes, panzvimbo yekuputika uye inhibit phagocytosis, kusunungurwa kwe lysosomal enzymes, uye synthesis uye kusunungurwa kwemakemikari ekuvhiringidza.
2. Immunosuppressive effects: kusanganisira kudzivirira kana kuvharidzira maitiro ezvirwere zvekudzivirira masero, kunonoka kwemaitiro emagetsi, kuderedza nhamba yeT lymphocytes, monocytes, uye eosinophils, kuderedza kukwanisa kusungirirwa kwema immunoglobulins kune cell surface receptors, uye inhibiting synthesis uye kusunungurwa kwe interleukins. , nokudaro kuderedza kutendeuka kweT lymphocytes kune lymphoblasts uye kuderedza kuwedzera kwekutanga kwekudzivirira zvirwere.Iyo inoderedza kupfuura kwema immune complexes kuburikidza nekamuri yepasi uye inoderedza kuwanda kwezvinhu zvinopindirana uye immunoglobulins.
Inotorwa nyore nyore kubva kuGI turakiti, ine plasma T1/2 ye190 maminetsi uye tishu T1/2 yemazuva matatu.Nhamba yepamusoro yeropa inosvika paawa imwe nemaawa masere mushure mejekiseni remumuscular ye dexamethasone sodium phosphate kana dexamethasone acetate, maererano.Iprotein yeplasma inosunga chiyero chechigadzirwa ichi yakaderera pane imwe corticosteroids, uye basa rinopesana nekuputika kwechigadzirwa ichi 0.75 mg yakaenzana ne5 mg ye prednisolone.
