Products
Doxifluridine
Structural Formula
Zvenyama
Chitarisiko:white Solid
Density: 1.3751 (kufungidzira)
Kunyungudika: 188-192 °c (lit.)
Chaiyo Kutenderera :d25 +18.4° (c = 0.419 Mumvura)
Refractivity: 20 °(c=1, H2o)
Storage Mamiriro: inert Atmosphere, kamuri Tembiricha
Acidity Factor(pka):7.4(pa25℃)
Safety Data
Chikamu chengozi:Zvisina zvinhu zvine ngozi
Kutakura zvinhu zvine njodzi nhamba:
Packaging category:
Application
1. Seprodrug ye5-Flurouridine.A fluorinated pyrimidine nucleoside ine cytostatic chiitiko.Clinically inoshandiswa kune gastric cancer, colorectal cancer, cancer yemazamu, chiyero chekuregererwa chinogona kusvika kupfuura 30%
2. Sepakati peFluorouracil antitumor zvinodhaka
Nhanganyaya yekushandisa
1. Fluorouracil-based antitumour agents ndiwo anotangira kufluorouracil.Iyo enzyme thymidine phosphorylase, iyo iripo mune bundu tishu, inoshanda pairi kuishandura kuita fluorouracil mubundu, nekudaro ichiita anti-bundu mhedzisiro.Iyo ine yakasimba anti-tundu chaiyo uye yakaderera toxicity.Inoshandiswa mukiriniki mugomarara remudumbu, colorectal cancer uye kenza yemazamu, ine chiyero chekuregererwa kusvika ku30% kana kupfuura.
2. Pharmaceutical yepakati.
3. Iro antitumour agent, precursor drug of fluorouracil (5-FU), iyo inoshandurwa kuva fluorouracil yakasununguka nekuita kwe pyrimidine nucleoside phosphorylase mumasumbu emamota, nokudaro ichidzivisa biosynthesis yeDNA neRNA mumasero emamota uye kuratidza ayo. antitumor effect.Sezvo kuita kweiyi enzyme kwakakwira mumatumbu ematishu pane akajairwa matishu, shanduko ye5-FU kuita 5-FU mumatumbu ematumbu inokurumidza uye inosarudza mabundu.Inoshandiswa mukurapa mazamu, dumbu uye rectal gomarara uye ine yakaderera toxicity.
