Munguva pfupi yadarika, vaongorori kubva kuGeorgia State University neTufts University vakawana kuti folic acid inogona kukurudzira stem cell kuwanda kuburikidza nein vitro tsika nemhando yemhuka masisitimu, izvo zvisingaenderane nebasa rayo sevhitamini, uye tsvakiridzo yakakodzera yakaburitswa mujenali yepasirese. Sero Yekuvandudza.
Folic acid, ingave iri yekuwedzera B vhitamini kana yakasikwa folic acid inotorwa muchikafu, inodiwa pakushanda kwakaringana kwemaseru ese emumuviri uye yakakosha kudzivirira hurema hwekukura muvana vachangozvarwa.Muchinyorwa ichi, vaongorori vakatanga kuona kuti vanhu vakuru stem cell vanhu vanogona kudzorwa nechinhu chinobva kunze kwemuviri wemhuka, kureva, folic acid kubva kubhakitiriya, senge nematodes mhando seCaenorhabditis elegans.
Mutsvakurudzi Edward Kipreos akati chidzidzo chedu chinoratidza kuti germ stem cells mu caenorhabditis elegans inogona kugoverwa ne folate stimulation kubva mukudya kwebhakitiriya;folic asidhi inodiwa B vhitamini, asi vaongorori vakawana kuti kugona kweyakakosha folic acid kukurudzira masero eutachiona kungasatsamira pabasa rayo sevhitamini B, izvo zvinogona kuratidza kuti folic acid inoita basa rakananga sechiratidzo chemorekuru.
Zvinongoitika zvega folic acid inowanzouya mumhando dzakawanda dzemakemikari, senge folic acid muchikafu kana iyo metabolically inoshanda fomu yefolic acid mumuviri wemunhu, uye folic acid inowanikwawo mumhando huru yekugadzira muzvikafu zvakasimbiswa uye mavhitamini ekuwedzera.Folic acid yakawanikwa muna 1945, kubva musi wekuwanikwa kwayo, vatsvakurudzi vakawanda vakaidzidza zvakanyanya, uye ikozvino kune anopfuura 50,000 mapepa ekutsvakurudza ane chokuita nefolic acid, asi chidzidzo ichi chinonyanya kukosha, nokuti chidzidzo chinoratidza basa idzva. yefolic acid, panzvimbo pebasa refolic acid rakaratidzwa mune zvidzidzo zvekare.
Folic acid ikozvino yakawedzerwa kuzviyo muUnited States nedzimwe nyika, uye folic acid supplementation inogona kubatsira zvakanyanya kuderedza kuberekwa kwevana vane neural tube development defects, asi folic acid basa rekusavimba nemavhitamini rinogona kubatsira kupa imwe nzira yechipiri. muviri wemunhu.Muchinyorwa ichi, vaongorori vakawana kuti yakakosha folate receptor inodaidzwa kuti FOLR-1 inofanirwa kukurudzira kukura kwemaseru ekuberekana stem maseru mumuviri weCaenorhabditis elegans.
Panguva imwecheteyo, vatsvakurudzi vakacherechedzawo maitiro eFOLR-1 receptors anokurudzira hutachiona hwehutachiona mu caenorhabditis elegans, iyo inogona kufanana nemaitiro efolic acid receptors inokurudzira kufambira mberi kwekenza yakakosha muzvisikwa zvevanhu;hongu, zvinogamuchirwa zvingave zvisingadikanwi pakutakura folic acid mumaseru kuitira kushandiswa kwevhitamini, asi zvinogona kukurudzira kupatsanurwa kwesero.Chekupedzisira, vaongorori vanoti chidzidzo ichi chinogona kutipawo chishandiso chitsva chekubatsira kudzidza iwo makuru emhando yemhando zvipenyu.
Nguva yekutumira: Mar-30-2022