Products
Polyinosinic Acid-polycytidylic Acid
Structural Formula
Zvenyama
Kuonekwa: chena kana isina-chena poda
Density.
Melting point.
Boiling point.
Refractivity
Flash point.
Safety Data
Hazardous category.
Nhamba Yekutakura Zvinhu Nengozi.
Packing category.
Application
Poly I: C inozivikanwa kudyidzana netoll-like receptor 3 (TLR3), iyo inoratidzwa paendosomal membrane yeB-masero, macrophages uye dendritic masero.Poly I:C yakarongeka yakafanana neRNA ine tambo mbiri, iripo mune mamwe mavhairasi uye "yakasikwa" inosimudzira TLR3.Nekudaro, Poly I: C inogona kutorwa seyakagadzirwa analog yeRNA yakasungwa kaviri uye chishandiso chakajairika chekutsvaga kwesainzi pane immune system.
Hunhu
Ichi chigadzirwa ndeye synthetic interferon inducer, inova polyribonucleotide ine tambo mbiri inoumbwa ne polyinosinic acid uye polycytidylic acid.Sezvo interferon iri mhando-yakananga, zvakaoma kugadzirira huwandu hwakawanda hwekushandiswa kwekliniki, saka inonyanya kushandiswa se interferon inducer kuti iite interferon.Mukuwedzera, polyinosinic acid ichine basa rekudzivirira muviri, iyo inogona kukurudzira reticuloendothelial system, kuwedzera phagocytic basa re phagocytes, kuwedzera kuumbwa kwemasoja ekudzivirira zvirwere, kukurudzira allograft reaction uye kunonoka kukanganiswa kwemaitiro.Iyo ine yakakura-spectrum antiviral uye antitumor mhedzisiro.
Kushandisa uye synthesis nzira
Overview
Polycytidylic acid, inozivikanwawo sepolyinosinic acid, polyhypoxanthine nucleotide uye polycytidine nucleotide, imwe yemapolynucleotides, ayo anoumbwa nekaviri-stranded polynucleotide cheni ye polyinosinic acid uye polycytidylic acid, ine hunhu hwekubvisa ruvara uye painonyungudika, uye 20s ℃. .
Pharmacological madhara
1. Polyinosinic acid ine maitiro akanaka ekusimudzira pane zvese zvakananga uye zvisiri izvo zvekudzivirira kwemuviri.
(1) Polymyocytes inowedzera kushanda kwemasero ekudzivirira
(2) Polymyocytes inokurudzira kuvharwa kwema cytokines akasiyana-siyana
(3) Induction yeMx protein ne polymyocytes
(4) Polymyocytes inosimudzira kugadzirwa kwemasoja ekudzivirira chirwere mu vivo
2. Anti-viral effect ye polymyocytes
In vitro bvunzo, kuongororwa kwemhuka uye kuyedzwa kwekiriniki kwevanhu kwakaratidza kuti polymyxins ine huwandu hwakawanda hwehutachiona hwehutachiona, hunosanganisira yellow fever virus, encephalomyelitis virus, Rift Valley fever virus, avian influenza virus, hepatitis virus, AIDS, tsoka-uye-muromo. chirwere chetachiona, conjunctivitis virus, simple rash virus, Mengo virus, pox virus, myocarditis virus, Aleutian virus, coxsackievirus, etc. Zvave zvichiratidzwa kuti kudzivirira kwePolymyxa kuri nani pane kurapa kwehutachiona hwehutachiona.
Application
1.Homopolymer ine tambo mbiri inogona kushandiswa semuenzaniso weRNA kudzidza kusaina kwesero padanho reTLR3 ichiziva RNA ine tambo mbiri, inovawo mugumisiro mukuru wekupindura kwemuviri kune hutachiona hwehutachiona.
2.Paired ne polyinosinic acid kuti iite polyinosinic cell, inoshandiswa pakurapa viral hepatitis, herpes zoster, herpes simplex keratitis, herpes stomatitis, epidemic hemorrhagic fever, nezvimwewo.
3. Iine immune adjuvant effect, inokurudzira reticuloendothelial system, inowedzera phagocytosis, inowedzera kuumbwa kwemasoja ekudzivirira muviri, inokurudzira allograft reaction uye kunonoka kukanganiswa kwemaitiro.Iyo ine yakakura-spectrum antiviral effect uye antitumor effect.Inonyanya kushandiswa kuchipatara kune: kudzivirira kana kurapwa kwehutachiona hwehutachiona, kurapwa kweherpes zoster, herpetic keratitis, viral hepatitis.Adjuvant kurapwa kwemamota.Zvakaipa zvinonyanya zvinosanganisira kutonhora kwemuviri kwenguva pfupi uye zviitiko zvemunhu ega efivha yakanyanya kupfuura 38 ℃, iyo kazhinji inopera yega mukati memazuva 1-2.Kana fivha isingasviki mukati memazuva maviri, mushonga unofanirwa kuregwa pakarepo.Kushaya simba, muromo wakaoma, dzungu, kuputika, nezvimwewo zvinoonekwawo.
