Products
2,6-Di-tert-butyl-4-methylpyridine
Structural Formula
Kuonekwa: white acicular crystal
Density: 1,476 g/cm3
Kunyungudika: 31-32 ℃
Poindi yekubikira: 148-153 ℃ (12.6kPa)
Refractive index: N20 /D 1.4763(lit.)
Painopenya: 183 °F
Kuchengetedza mamiriro: 2-8°C
Acidity coefficient (pKa): 6.88±0.10(Yakafanotaurwa)
Safety Data
Ndeye general cargo
Tsika kodhi: 2942000000
Export mutero wekudzoreredza mwero (%) : 13%
Application
Organic synthetic yepakati, yakavharirwa, isiri-nucleophilic base iyo inosiyanisa pakati peBrnsted (protonic) neLewis acids.Inogonesa kushandurwa kwakananga kwegoho repamusoro realdehydes1 uye ketones1,2 kuita vinyl triflates.
2,6-Di-tert-butyl-4-methylpyridine is organic compound ine molecular formula C14H23N, yakakosha yepakati muorganic synthesis, inonyanya kushandiswa mumishonga yepakati, organic synthesis, organic solvents, zvakare inogona kushandiswa mukugadzira dhayi, pesticide. kugadzirwa uye zvinonhuwira, nezvimwewo.
Nzira yekugadzira
1. Gadzira 2,6 di-tert-butyl-4-methylbenzyl trifluoromethanesulfonate Mu 100-mL katatu flask yakagadzirwa ne nitrogen introduction chubhu, inoramba iine pressure funnel, electromagnetic stirring bar uye ice condenser ine yakaoma chubhu, wedzera 24.2 g (0.2 mol) ye trimethylethyl phthalide chloride uye 3.7 g (0.05 mol) ye tert-butanol.Musanganiswa wekuita wakapiswa mubhavhu remafuta kusvika 85 ° C.Zvadaro 15 g (0.1 mol) ye trifluoromethanesulfonic acid yakawedzerwa kwemaminetsi anopfuura gumi nemashanu.Mhedzisiro yacho yakaenderera mberi kwemaminetsi gumi, uye chigadzirwa chechiedza chebrown chakanyoroveswa mubhati rechando ndokudururirwa mu100 ml yechando ether.Iyo yebrown precipitate yakasefa uye yakaomeswa kuti iwane 9.6 g (54%) yeinononoka buzz munyu.(Hapana kucheneswa kunodiwa: padanho rinotevera rekugadzirira, dzokorora kaviri kubva kuchloroform kuenda kucarbon tetrachloride 3:1) kune makristasi asina ruvara akafanana netsono.
2. Kugadzirira kwe2,6-Di-tert-butyl-4-methyl-vizine Pasi pekugadzirisa, kumira kwe10 g (0.028 mol) yemunyu usina kuchena wevizine mu 200 mL ye95% ethanol yakatonhora kusvika 60 ° C yakanga. yakawedzerwa kamwe ku100 mL yeammonia yakanyungudutswa yakanyungudutswa kusvika 60°C mu1-lita yebindu-pasi flask.Mhedzisiro yacho yakaenderera mberi pa60 ° C kwemaminitsi makumi matatu uye 40 ° C kwemaawa maviri, panguva iyo kumiswa kwakapera.Zvadaro, musanganiswa wekuita wakadururwa mu 500 ml ye 2% sodium hydroxide solution zvishoma nezvishoma ichidziya kusvika kune kamuri tembiricha.Yakabviswa ne .4-100 ml yepentane, yakasanganiswa zvinyorwa, 25 ml ye saturated sodium chloride solution yakashambidzwa, 100 ml yepentane rotary evaporator concentration.
