3,3'- diindolylmethane

Tsanangudzo Pfupi

3,3'- diindolylmethane (3,3'-diindolylmethane) ichena kusvika kuchena crystalline poda, iyo inonyungudika mu methanol, ethyl acetate, dichloromethane uye mamwe organic solvents.3,3'- diindole methane inowanikwa zvakanyanya mumiti yepanyama yeCruciferae.Iyo ine yakakosha biological uye pharmacological zviitiko uye inoshandiswa zvakanyanya mumunda wemishonga uye hutano zvigadzirwa.3,3'-diindolylmethane (DIM) ndiyo inonyanya kugayiwa chigadzirwa cheindole-3-carbinol, iyo inogona kuita anticancer chinhu mumiriwo yecruciferous.3,3′-diindolylmethane (DIM) mupikisi akasimba weyakachena Android receptor (AR).

Tumira email kwatiri

Product Detail

Product Tags

Tsanangudzo

3,3'-diindolylmethane imishonga yepakati;Inogona kuwanikwa mune zvepanyama phytochemicals zveCruciferae Plants, acid catalyzed reaction products, indole-3-methanol;Iine basa re anti-tumor agent;Pasi pemamiriro ekunyanya kudzikamisa, iyo inotorwa haingogone kumhanyisa zvakananga apoptosis yemasero egomarara remunhu, asi zvakare kukurudzira nzira yekukurudzira apoptosis yekenza yemunhu maseru;Chemicalbookdim induces a G1 cell ring inhibition mukenza yemazamu yemunhu MCF-7 masero kuburikidza nemaitiro uye kubatanidza kutaura;Dim inhibitor ine simba ye mitochondrial h + -atpase;Semutsigiri mutsva wekukura kwechirimwa, dim uye zvinobva pairi zvakashandiswa mukutsvagisa eco-hushamwari system.

Product Info

Cas Nhamba: 1968-05-4

Kuchena: ≥98%

Fomula: C17H14N2

Formula Wt.:246.31

Kemikari Zita:3,3'-Diindolylmethane

Synonym ： :3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl);Plant:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE

Kunyungudika: 167 °C

Nzvimbo yekubika: 230 ° C

Solubility: Chloroform (Zvishoma), Methanol (Zvishoma)

Chitarisiko: Off-white powder

Kutumira uye Kuchengeta

Kugadzikana kwekuchengetedza Inokurudzirwa tembiricha yekuchengetera -20°C.

Gadziriro Isa indole (1.17 g, 10 mmol), CTAB (50% mol) uye oxalic acid (50% mol) mu 25 ml single-necked round-pasi flask, wedzera 5 ml yemvura yakasvibiswa, simbisa zvakakwana kwemaminitsi mashanu uye ipapo. wedzera aqueous formaldehyde solution (0.38 g solution, 5 mmol formaldehyde) dropwise.React kwe3 h pakamuri tembiricha uye rega kuita.Mhinduro yekugadzirisa yakatorwa ne 15 ml ye ethyl acetate muzvikamu zvitatu, uye chikamu chehupenyu chakaunganidzwa uye chakaomeswa neanhydrous Na2SO4 kwemaawa mashanu.Mushonga wacho wakabviswa pasi pekudzvinyirirwa kwakaderera uye wakagadziridzwa kubva musanganiswa we methanol nemvura (methanol/H2ChemicalbookO = 10/1) kuti ipe chena yakasimba 3,3'-diindolylmethane mu 85% goho.Bioactivity3,3'-Diindolylmethane (DIM) ndiyo inonyanya kugayiwa chigadzirwa che indole-3-carbinol, iyo inogona kuita anticancer zvinhu mumiti yecruciferous.3,3'-Diindolylmethane (DIM) inopikisa yakachena yakasimba ye androgenreceptor (AR) .
In vitro zvidzidzo zvakaratidza kuti DIM inoshanda radioprotector uye mitigator, ichiita nekukurudzira ATM-inotyairwa DDR-kufanana mhinduro pamwe neNF-κB kupona kusaina.DIM inogona kuvharira bundu cell invasion, angiogenesis, kupararira uye kuitisa apoptosis nemodulating masaini nzira. zvakadai seAKT, NF-κB uye FOXO3.Inogonawo kurambidza estrogen-induced gene expression uye kukurudzira endoplasmic reticulum stress.ChemicalbookDIM inogona kushandura estrogen metabolism uye kupikisa estrogen uye androgen receptor chiitiko.In vivo zvidzidzo zvakaratidza kuti DIM inoshanda kurwisa systemic radiation mushure mekuita kwakawanda.Mune in vivo bvunzo, DIM yakapa kudzivirirwa kwemwaranzi kana kuderedza.Mune zvakajairika tishu, DIM inomutsa ATM.diM inogona kupihwa kune mbeva nekuzadza nemuromo (250 mg/kg) ine yakakwirira bioavailability uye isina acute t.

Zvakapfuura: China Indole Manufacture Supplier

Zvinotevera: China Indole-3-methanol Manufacture Supplier